Even when the levels haven't changed, when running as a reaper plugin, I'm getting some annoying feedback/noises in the background, which can only be removed by using very low gain or turning the tone pot on the guitar right down (I don't have to do this outside of Reaper). Only problem is when I open up reaper (64bit).
My electric guitar (Ibanez) goes through a Scarlett Focusrite interface, then in to my PC (windows 10), and when I do this with GR5 as a standalone desktop APP it is pretty easy to use and sounds pretty good. For those able to help, just ask for whatever info I seem to have missed and hopefully I can find that out so we can troubleshoot.
I'm having some trouble using GR5 in Reaper to achieve a good quality sound, so I want to write down everything I can think of that might be relevant.